Ontology highlight
ABSTRACT:
SUBMITTER: Rashdan HRM
PROVIDER: S-EPMC8399954 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Rashdan Huda R M HRM Shehadi Ihsan A IA Abdelrahman Mohamad T MT Hemdan Bahaa A BA
Molecules (Basel, Switzerland) 20210809 16
In this study, a new synthetic 1,2,3-triazole-containing disulfone compound was derived from dapsone. Its chemical structure was confirmed using microchemical and analytical data, and it was tested for its in vitro antibacterial potential. Six different pathogenic bacteria were selected. MICs values and ATP levels were determined. Further, toxicity performance was measured using MicroTox Analyzer. In addition, a molecular docking study was performed against two vital enzymes: DNA gyrase and Dihy ...[more]