Milk Osteopontin for Gut, Immunity and Brain Development in Preterm Pigs.

ABSTRACT: Deficient levels of milk osteopontin (OPN) in infant formula may partly account for developmental differences between infants fed formula or maternal milk. We hypothesized that a milk diet supplemented with bovine milk OPN improves gut, immunity and brain development and tested this in a preterm pig model. Preterm pigs delivered by cesarean section (90% gestation) were fed raw bovine milk (CON, n = 19) or the same diet supplemented with a physiologically relevant dose of OPN (46 mg/(kg·d), n = 16). Endpoints related to clinical outcomes, systemic immunity and neurocognitive development were assessed during the study and gut tissues were collected at Day 19. Growth pattern, early motor development and most systemic immune parameters were similar between OPN and CON pigs. The OPN pigs had hi

SUBMITTER: Aasmul-Olsen K 

PROVIDER: S-EPMC8400468 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature