Outcomes among patients with breakthrough SARS-CoV-2 infection after vaccination in a high-risk national population.

ABSTRACT:

Background

Breakthrough infections after SARS-CoV-2 infection have been reported. Clinical outcomes among persons with breakthrough infection are not known.

Methods

We retrospectively identified all Veterans with a confirmed SARS-CoV-2 infection >14 days after the second dose of either Pfizer-BNT-162b2 or Moderna-mRNA-1273 vaccine between December 15, 2020 and March 30, 2021, and age, race, sex, body mass index, Charlson comorbidity index, geographical location, and date of positive test matched unvaccinated controls with SARS-CoV-2 infection. Our primary endpoint was the rate or severe disease defined as hospitalization, mechanical ventilation, or death in both groups.

Findings

Among 258,716 persons with both doses of vaccines and 756,150 without any vaccination, we

SUBMITTER: Butt AA 

PROVIDER: S-EPMC8400515 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature