Normothermic Machine Perfusion (NMP) of the Liver - Current Status and Future Perspectives.

ABSTRACT: A shortage of available organs for liver transplantation has led transplant surgeons and researchers to seek for innovative approaches in hepatoprotection and improvement of marginal allografts. The most exciting development in the past decade has been continuous mechanical perfusion of livers with blood or preservation solution to mitigate ischemia-reperfusion injury in contrast to the current standard of static cold storage. Two variations of machine perfusion have emerged in clinical practice. During hypothermic oxygenated perfusion the liver is perfused using a red blood cell-free perfusate at 2-10°C. In contrast, normothermic machine perfusion mimics physiologic liver perfusion using a red blood cell-based solution at 35.5-037.5°C, offering a multitude of potential advantages. Putativ

SUBMITTER: van Beekum CJ 

PROVIDER: S-EPMC8400594 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature