Differential Effects of Dietary Components on Glucose Intolerance and Non-Alcoholic Steatohepatitis.

ABSTRACT: Pharmacological treatment modalities for non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) are scarce, and discoveries are challenged by lack of predictive animal models adequately reflecting severe human disease stages and co-morbidities such as obesity and type 2 diabetes. To mimic human NAFLD/NASH etiology, many preclinical models rely on specific dietary components, though metabolism may differ considerably between species, potentially affecting outcomes and limiting comparability between studies. Consequently, understanding the physiological effects of dietary components is critical for high translational validity. This study investigated the effects of high fat, cholesterol, and carbohydrate sources on NASH development and metabolic outcomes in guinea pigs. Diet gr

SUBMITTER: Skat-Rordam J 

PROVIDER: S-EPMC8400624 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature