Disconnectome of the migraine brain: a "connectopathy" model.

ABSTRACT:

Background

In the past decades a plethora of studies has been conducted to explore resting-state functional connectivity (RS-FC) of the brain networks in migraine with conflicting results probably due to the variability and susceptibility of signal fluctuations across the course of RS-FC scan. On the other hand, the structural substrates enabling the functional communications among the brain connectome, characterized by higher stability and reproducibility, have not been widely investigated in migraine by means of graph analysis approach. We hypothesize a rearrangement of the brain connectome with an increase of both strength and density of connections between cortical areas specifically involved in pain perception, processing and modulation in migraine patients. Moreover, such con

SUBMITTER: Silvestro M 

PROVIDER: S-EPMC8400754 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature