Associations between the gut microbiome and metabolome in early life.

ABSTRACT:

Background

The infant intestinal microbiome plays an important role in metabolism and immune development with impacts on lifelong health. The linkage between the taxonomic composition of the microbiome and its metabolic phenotype is undefined and complicated by redundancies in the taxon-function relationship within microbial communities. To inform a more mechanistic understanding of the relationship between the microbiome and health, we performed an integrative statistical and machine learning-based analysis of microbe taxonomic structure and metabolic function in order to characterize the taxa-function relationship in early life.

Results

Stool samples collected from infants enrolled in the New Hampshire Birth Cohort Study (NHBCS) at approximately 6-weeks (n = 158) and 12-mo

SUBMITTER: Nguyen QP 

PROVIDER: S-EPMC8400760 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature