Selenium Modulates the Allergic Response to Whey Protein in a Mouse Model for Cow's Milk Allergy.

ABSTRACT: Cow's milk allergy is a common food allergy in infants, and is associated with an increased risk of developing other allergic diseases. Dietary selenium (Se), one of the essential micronutrients for humans and animals, is an important bioelement which can influence both innate and adaptive immune responses. However, the effects of Se on food allergy are still largely unknown. In the current study it was investigated whether dietary Se supplementation can inhibit whey-induced food allergy in an animal research model. Three-week-old female C3H/HeOuJ mice were intragastrically sensitized with whey protein and cholera toxin and randomly assigned to receive a control, low, medium or high Se diet. Acute allergic symptoms, allergen specific immunoglobulin (Ig) E levels and mast cell degranulation

SUBMITTER: Zhao X 

PROVIDER: S-EPMC8400770 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature