Respiratory Colonization and Short-Term Temporal Changes in the Urinary Metabolome of Children.

ABSTRACT: The human metabolome may vary based on age, over time, and in the presence of viral carriage and bacterial colonization-a common scenario in children. We used nuclear magnetic resonance spectroscopy to identify and quantify urinary metabolites of children without signs or symptoms of respiratory illness. A urine sample and two nasopharyngeal swabs were collected to test for respiratory viral pathogens and colonization by Streptococcus pneumoniae (Sp). Urine samples were collected at the initial visit, 24 h post-enrollment, and 10-14 days post-enrollment. Of the 122 children enrolled, 24% had a virus detected and 19.7% had Sp detected. Intraclass correlation coefficients demonstrated greater within-subject versus between-subject variability for all metabolites detected. In linear mixed mode

SUBMITTER: Ambroggio L 

PROVIDER: S-EPMC8400807 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature