Increases in GFAP immunoreactive astrocytes in the cerebellar molecular layer of young adult CBA/J mice.

ABSTRACT:

Background

CBA/J mice are standard experimental animals in auditory studies, and age-related changes in auditory pathways are well documented. However, changes in locomotion-related brain regions have not been systematically explored.

Results

We showed an increase in immunoreactivity for glial fibrillary acidic protein (GFAP) in the cerebellar molecular layer associated with Purkinje cells in mice at 24 weeks of age but not in the younger mice. Increased GFAP immunoreactivity appeared in the form of clusters and distributed multifocally consistent with hyperplasia of astrocytes that were occasionally associated with Purkinje cell degeneration. Three out of 12 animals at 16 and 24 weeks of age exhibited pre-convulsive clinical signs. Two of these 3 animals also showed increas

SUBMITTER: Tyszkiewicz C 

PROVIDER: S-EPMC8400896 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature