Genome-wide association study identifies a novel maternal gene × stress interaction associated with spontaneous preterm birth.

ABSTRACT:

Background

Maternal stress is potentially a modifiable risk factor for spontaneous preterm birth (sPTB). However, epidemiologic findings on the maternal stress-sPTB relationship have been inconsistent.

Methods

To investigate whether the maternal stress-sPTB associations may be modified by genetic susceptibility, we performed genome-wide gene × stress interaction analyses in 1490 African-American women from the Boston Birth cohort who delivered term (n = 1033) or preterm (n = 457) infants. Genotyping was performed using Illumina HumanOmni 2.5 array. Replication was performed using data from the NICHD genomic and Proteomic Network (GPN) for PTB research.

Results

rs35331017, a T-allele insertion/deletion polymorphism in the protein-tyrosine phosphatase receptor Type D (P

SUBMITTER: Hong X 

PROVIDER: S-EPMC8400921 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature