Mannitol Polymorphs as Carrier in DPIs Formulations: Isolation Characterization and Performance.

ABSTRACT: The search for best performing carriers for dry powder inhalers is getting a great deal of interest to overcome the limitations posed by lactose. The aerosolization of adhesive mixtures between a carrier and a micronized drug is strongly influenced by the carrier solid-state properties. This work aimed at crystallizing kinetically stable D-mannitol polymorphs and at investigating their aerosolization performance when used in adhesive mixtures with two model drugs (salbutamol sulphate, SS, and budesonide, BUD) using a median and median/high resistance inhaler. A further goal was to assess in vitro the cytocompatibility of the produced polymer-doped mannitol polymorphs toward two lung epithelial cell lines. Kinetically stable (up to 12 months under accelerate conditions) α, and δ mannitol fo

SUBMITTER: Altay Benetti A 

PROVIDER: S-EPMC8401007 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature