Serum 25-Hydroxyvitamin D Concentrations and Atopic Dermatitis in Early Childhood: Findings from the Japan Environment and Children's Study.

ABSTRACT: Vitamin D (VitD) may affect immune system modulation and result in the development of atopic dermatitis (AD). However, published findings have remained controversial. We investigated the association between early-life 25-hydroxyvitamin D (25(OH)D) levels and AD risk at childhood with a birth cohort. The data were obtained from "the Japan Environment and Children's Study (JECS)" and "the Sub-Cohort study of JECS" performed with children aged 2 years. "Liquid chromatography-tandem mass spectrometry" was used to measure VitD. The information on AD was obtained from parents' answers to a questionnaire when their children were aged 3 years. In order to explain the seasonal effects on VitD levels, a deseasonalized continuous variable was further calculated. The logistic regression models were fi

SUBMITTER: Yang L 

PROVIDER: S-EPMC8401201 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature