Protein Adducts and Protein Oxidation as Molecular Mechanisms of Flavonoid Bioactivity.

ABSTRACT: There are tens of thousands of scientific papers about flavonoids and their impacts on human health. However, despite the vast amount of energy that has been put toward studying these compounds, a unified molecular mechanism that explains their bioactivity remains elusive. One contributing factor to the absence of a general mechanistic explanation of their bioactivity is the complexity of flavonoid chemistry in aqueous solutions at neutral pH. Flavonoids have acidic protons, are redox active, and frequently auto-oxidize to produce an array of degradation products including electrophilic quinones. Flavonoids are also known to interact with specificity and high affinity with a variety of proteins, and there is evidence that some of these interactions may be covalent. This review summarizes t

SUBMITTER: Joyner PM 

PROVIDER: S-EPMC8401221 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature