Colonization of Clostridium butyricum in Rats and Its Effect on Intestinal Microbial Composition.

ABSTRACT: Gut microorganisms participate in many physiological processes. In particular, Clostridium butyricum can modulate gut microorganisms and treat diseases. The colonization and persistence of strains in the gut contribute to beneficial effects, and the colonization by C. butyricum in the gut is currently unknown. We investigated the total intestinal contents of C. butyricum at 12 h, 24 h, 48 h, and four and six days using real-time reverse transcription-PCR, after oral administration of C. butyricum to rats for seven consecutive days. We assessed the bacterial community structure using Illumina MiSeq sequencing. The results showed that C. butyricum was mainly colonized in the colon. The total content of C. butyricum in the gut increased significantly

SUBMITTER: Luo X 

PROVIDER: S-EPMC8401576 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature