Interaction of a Short Peptide with G-Quadruplex-Forming Sequences: An SRCD and CD Study.

ABSTRACT: G-quadruplex (G4) forming DNA sequences were recently found to play a crucial role in the regulation of genomic processes such as replication, transcription and translation, also related to serious diseases. Therefore, systems capable of controlling DNA and RNA G-quadruplex structures would be useful for the modulation of various cellular events. In particular, peptides represent good candidates for targeting G-quadruplex structures, since they are easily tailored to enhance their functionality. In this work, we analyzed, by circular dichroism and synchrotron radiation circular dichroism spectroscopies, the interaction of a 25-residue peptide deriving from RHAU helicases (Rhau25) with three G-quadruplex-forming oligonucleotide sequences, in both sodium- and potassium-containing buffers, th

SUBMITTER: Honisch C 

PROVIDER: S-EPMC8401852 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature