Subtractive Genomics Approach for Identification of Novel Therapeutic Drug Targets in Mycoplasma genitalium.

ABSTRACT: Mycoplasma genitalium infection is a sexually transmitted infection that causes urethritis, cervicitis, and pelvic inflammatory disease (PID) in men and women. The global rise in antimicrobial resistance against recommended antibiotics for the treatment of M. genitalium infection has triggered the need to explore novel drug targets against this pathogen. The application of a bioinformatics approach through subtractive genomics has proven highly instrumental in predicting novel therapeutic targets against a pathogen. This study aimed to identify essential and non-homologous proteins with unique metabolic pathways in the pathogen that could serve as novel drug targets. Based on this, a manual comparison of the metabolic pathways of M. genitalium and the human host was do

SUBMITTER: Fatoba AJ 

PROVIDER: S-EPMC8402164 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature