Structure-Dependent Stability of Lipid-Based Polymer Amphiphiles Inserted on Erythrocytes.

ABSTRACT: Cell-based therapies have the potential to transform the treatment of many diseases. One of the key challenges relating to cell therapies is to modify the cell surface with molecules to modulate cell functions such as targeting, adhesion, migration, and cell-cell interactions, or to deliver drug cargos. Noncovalent insertion of lipid-based amphiphilic molecules on the cell surface is a rapid and nontoxic approach for modifying cells with a variety of bioactive molecules without affecting the cellular functions and viability. A wide variety of lipid amphiphiles, including proteins/peptides, carbohydrates, oligonucleotides, drugs, and synthetic polymers have been designed to spontaneously anchor on the plasma membranes. These molecules typically contain a functional component, a spacer, and

SUBMITTER: Yu C 

PROVIDER: S-EPMC8402226 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature