Long-Term Follow-Up of Gemogenovatucel-T (Vigil) Survival and Molecular Signals of Immune Response in Recurrent Ovarian Cancer.
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ABSTRACT:
SUBMITTER: Rocconi RP
PROVIDER: S-EPMC8402348 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Long-Term Follow-Up of Gemogenovatucel-T (Vigil) Survival and Molecular Signals of Immune Response in Recurrent Ovarian Cancer.
Rocconi Rodney P RP Stanbery Laura L Madeira da Silva Luciana L Barrington Robert A RA Aaron Phylicia P Manning Luisa L Horvath Staci S Wallraven Gladice G Bognar Ernest E Walter Adam A Nemunaitis John J
Vaccines 20210812 8
<h4>Aim</h4>To determine the relationship between gene expression profile (GEP) and overall survival (OS) by NanoString following treatment with Vigil.<h4>Patients and methods</h4>Recurrent ovarian cancer patients (<i>n</i> = 21) enrolled in prior clinical trials.<h4>Results</h4>GEP stratified by TIS<sup>HIGH</sup> vs. TIS<sup>LOW</sup> demonstrated OS benefit (NR vs. 5.8 months HR 0.23; <i>p</i> = 0.0379), and in particular, MHC-II elevated baseline expression was correlated with OS advantage ( ...[more]
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