Origin and Characterization of Extracellular Vesicles Present in the Spider Venom of Ornithoctonus hainana.

ABSTRACT: Extracellular vesicles (EVs), including exosomes and microvesicles, are membranous vesicles released from nearly all cellular types. They contain various bioactive molecules, and their molecular composition varies depending on their cellular origin. As research into venomous animals has progressed, EVs have been discovered in the venom of snakes and parasitic wasps. Although vesicle secretion in spider venom glands has been observed, these secretory vesicles' origin and biological properties are unknown. In this study, the origin of the EVs from Ornithoctonus hainana venom was observed using transmission electron microscopy (TEM). The Ornithoctonus hainana venom extracellular vesicles (HN-EVs) were isolated and purified by density gradient centrifugation. HN-EVs possess class

SUBMITTER: Xun C 

PROVIDER: S-EPMC8402349 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature