T-Cell Cytokine Response in Salmonella Typhimurium-Vaccinated versus Infected Pigs.

ABSTRACT: Vaccination with the live attenuated vaccine Salmoporc is an effective measure to control Salmonella Typhimurium (STM) in affected swine populations. However, the cellular immune response evoked by the Salmoporc vaccine including differences in vaccinated pigs versus non-vaccinated pigs upon STM infection have not been characterized yet. To investigate this, tissue-derived porcine lymphocytes from different treatment groups (vaccination-only, vaccination and infection, infection-only, untreated controls) were stimulated in vitro with heat-inactivated STM and abundances of IFN-γ, TNF-α and/or IL-17A-producing T-cell subsets were compared across organs and treatment groups. Overall, our results show the induction of a strong CD4⁺ T-cell response after STM infection, both lo

SUBMITTER: Schmidt S 

PROVIDER: S-EPMC8402558 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature