Modeling Within-Host Dynamics of SARS-CoV-2 Infection: A Case Study in Ferrets.

ABSTRACT: The pre-clinical development of antiviral agents involves experimental trials in animals and ferrets as an animal model for the study of SARS-CoV-2. Here, we used mathematical models and experimental data to characterize the within-host infection dynamics of SARS-CoV-2 in ferrets. We also performed a global sensitivity analysis of model parameters impacting the characteristics of the viral infection. We provide estimates of the viral dynamic parameters in ferrets, such as the infection rate, the virus production rate, the infectious virus proportion, the infected cell death rate, the virus clearance rate, as well as other related characteristics, including the basic reproduction number, pre-peak infectious viral growth rate, post-peak infectious viral decay rate, pre-peak infectious viral

SUBMITTER: Vaidya NK 

PROVIDER: S-EPMC8402735 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature