Hantavirus Replication Cycle-An Updated Structural Virology Perspective.

ABSTRACT: Hantaviruses infect a wide range of hosts including insectivores and rodents and can also cause zoonotic infections in humans, which can lead to severe disease with possible fatal outcomes. Hantavirus outbreaks are usually linked to the population dynamics of the host animals and their habitats being in close proximity to humans, which is becoming increasingly important in a globalized world. Currently there is neither an approved vaccine nor a specific and effective antiviral treatment available for use in humans. Hantaviruses belong to the order Bunyavirales with a tri-segmented negative-sense RNA genome. They encode only five viral proteins and replicate and transcribe their genome in the cytoplasm of infected cells. However, many details of the viral amplification cycle are stil

SUBMITTER: Meier K 

PROVIDER: S-EPMC8402763 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature