Structural 3D Domain Reconstruction of the RNA Genome from Viruses with Secondary Structure Models.

ABSTRACT: Three-dimensional RNA domain reconstruction is important for the assembly, disassembly and delivery functionalities of a packed proteinaceus capsid. However, to date, the self-association of RNA molecules is still an open problem. Recent chemical probing reports provide, with high reliability, the secondary structure of diverse RNA ensembles, such as those of viral genomes. Here, we present a method for reconstructing the complete 3D structure of RNA genomes, which combines a coarse-grained model with a subdomain composition scheme to obtain the entire genome inside proteinaceus capsids based on secondary structures from experimental techniques. Despite the amount of sampling involved in the folded and also unfolded RNA molecules, advanced microscope techniques can provide points of anchor

SUBMITTER: Poblete S 

PROVIDER: S-EPMC8402887 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature