Intercalated amygdala clusters orchestrate a switch in fear state.

ABSTRACT: Adaptive behaviour necessitates the formation of memories for fearful events, but also that these memories can be extinguished. Effective extinction prevents excessive and persistent reactions to perceived threat, as can occur in anxiety and 'trauma- and stressor-related' disorders¹. However, although there is evidence that fear learning and extinction are mediated by distinct neural circuits, the nature of the interaction between these circuits remains poorly understood^2-6. Here, through a combination of in vivo calcium imaging, functional manipulations, and slice physiology, we show that distinct inhibitory clusters of intercalated neurons (ITCs) in the mouse amygdala exert diametrically opposed roles during the acquisition and retrieval of fear extinction memory. F

SUBMITTER: Hagihara KM 

PROVIDER: S-EPMC8402941 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature