The Genetic Epidemiology of Joint Shape and the Development of Osteoarthritis.

ABSTRACT: Congruent, low-friction relative movement between the articulating elements of a synovial joint is an essential pre-requisite for sustained, efficient, function. Where disorders of joint formation or maintenance exist, mechanical overloading and osteoarthritis (OA) follow. The heritable component of OA accounts for ~ 50% of susceptible risk. Although almost 100 genetic risk loci for OA have now been identified, and the epidemiological relationship between joint development, joint shape and osteoarthritis is well established, we still have only a limited understanding of the contribution that genetic variation makes to joint shape and how this modulates OA risk. In this article, a brief overview of synovial joint development and its genetic regulation is followed by a review of current know

SUBMITTER: Wilkinson JM 

PROVIDER: S-EPMC8403114 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature