Characterizing neuroanatomic heterogeneity in people with and without ADHD based on subcortical brain volumes.

ABSTRACT:

Background

Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder. Neuroanatomic heterogeneity limits our understanding of ADHD's etiology. This study aimed to parse heterogeneity of ADHD and to determine whether patient subgroups could be discerned based on subcortical brain volumes.

Methods

Using the large ENIGMA-ADHD Working Group dataset, four subsamples of 993 boys with and without ADHD and to subsamples of 653 adult men, 400 girls, and 447 women were included in analyses. We applied exploratory factor analysis (EFA) to seven subcortical volumes in order to constrain the complexity of the input variables and ensure more stable clustering results. Factor scores derived from the EFA were used to build networks. A community detection (CD

SUBMITTER: Li T 

PROVIDER: S-EPMC8403135 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature