Lack of Associations Between C-Reactive Protein and Mood and Anxiety Symptoms in Adolescents.

ABSTRACT: Introduction: Increased peripheral inflammation has been consistently documented in both adult and pediatric depression. However, elevated levels of C-reactive protein (CRP), a nonspecific biomarker for inflammation, have been primarily reported in adults; whether CRP plays a similar role in adolescent depression has not been conclusively established. In our prior work, we identified relationships between CRP and reward neurocircuitry in adolescents with psychiatric symptoms (N = 64) but not with depressive symptoms. Extending this work, we sought to examine CRP across the full range of mood and anxiety symptom severity in a larger, clinically diverse cohort of psychotropic medication-free adolescents and healthy controls (HCs). Methods: Subjects were ado

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8403190 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature