Cangrelor: Clinical Data, Contemporary Use, and Future Perspectives.

ABSTRACT: Cangrelor is the only currently available intravenous platelet P2Y₁₂ receptor inhibitor. It is characterized by potent, predictable, and rapidly reversible antiplatelet effects. Cangrelor has been tested in the large CHAMPION (Cangrelor Versus Standard Therapy to Achieve Optimal Management of Platelet Inhibition) program, where it was compared with different clopidogrel regimens, and it is currently indicated for use in patients with coronary artery disease undergoing percutaneous coronary intervention. However, the uptake of cangrelor use varies across the globe and may also include patients with profiles different from those enrolled in the registration trials. These observations underscore the need to fully examine the safety and efficacy of cangrelor in postregistration stud

SUBMITTER: De Luca L 

PROVIDER: S-EPMC8403274 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature