Pathway analysis of glutamate-mediated, calcium-related signaling in glioma progression.

ABSTRACT: Brain tumors, particularly high-grade glioblastomas, are a crucial public health issue due to poor prognosis and an extremely low survival rate. The glioblastoma multiforme (GBM) grows rapidly within its unique microenvironment that is characterized by active neural communications. Therefore, diverse neurotransmitters not only maintain normal brain functions but also influence glioma progression. To fully appreciate the relationship between neurotransmitters and glioma progression, we reviewed potential neurotransmitter contributors in human GBM and the much less aggressive Low-grade glioma (LGG) by combining previously published data from gene-mutation/mRNA sequencing databases together with protein-protein interaction (PPI) network analysis results. The summarized results indicate that g

SUBMITTER: Pei Z 

PROVIDER: S-EPMC8403340 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature