Attenuating vascular stenosis-induced astrogliosis preserves white matter integrity and cognitive function.

ABSTRACT:

Background

Chronic cerebral hypoperfusion (CCH) causes white matter damage and cognitive impairment, in which astrogliosis is the major pathology. However, underlying cellular mechanisms are not well defined. Activation of Na⁺/H⁺ exchanger-1 (NHE1) in reactive astrocytes causes astrocytic hypertrophy and swelling. In this study, we examined the role of NHE1 protein in astrogliosis, white matter demyelination, and cognitive function in a murine CCH model with bilateral carotid artery stenosis (BCAS).

Methods

Sham, BCAS, or BCAS mice receiving vehicle or a selective NHE1 inhibitor HOE642 were monitored for changes of the regional cerebral blood flow and behavioral performance for 28 days. Ex vivo MRI-DTI was subsequently conducted to detect brain injury a

SUBMITTER: Liu Q 

PROVIDER: S-EPMC8403348 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature