Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects.

ABSTRACT:

Background

Exercise training is well established as the most effective way to enhance muscle performance and muscle building. The composition of skeletal muscle fiber type affects systemic energy expenditures, and perturbations in metabolic homeostasis contribute to the onset of obesity and other metabolic dysfunctions. Long noncoding RNAs (lncRNAs) have been demonstrated to play critical roles in diverse cellular processes and diseases, including human cancers; however, the functional importance of lncRNAs in muscle performance, energy balance, and obesity remains elusive. We previously reported that the lncRNA H19 regulates the poly-ubiquitination and protein stability of dystrophin (DMD) in muscular dystrophy.

Methods

Here, we identified mouse/human H19-interacting protei

SUBMITTER: Li Y 

PROVIDER: S-EPMC8403366 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature