Decreased pancreatic acinar cell number in type 1 diabetes.

ABSTRACT:

Aims/hypothesis

Individuals with longstanding and recent-onset type 1 diabetes have a smaller pancreas. Since beta cells represent a very small portion of the pancreas, the loss of pancreas volume in diabetes is primarily due to the loss of pancreatic exocrine mass. However, the structural changes in the exocrine pancreas in diabetes are not well understood.

Methods

To characterise the pancreatic endocrine and exocrine compartments in diabetes, we studied pancreases from adult donors with type 1 diabetes compared with similarly aged donors without diabetes. Islet cell mass, islet morphometry, exocrine mass, acinar cell size and number and pancreas fibrosis were assessed by immunohistochemical staining. To better understand possible mechanisms of altered pancreas size, we mea

SUBMITTER: Wright JJ 

PROVIDER: S-EPMC8403487 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature