Computationally grafting an IgE epitope onto a scaffold: Implications for a pan anti-allergy vaccine design.

ABSTRACT: Allergy is becoming an intensifying disease among the world population, particularly in the developed world. Once allergy develops, sufferers are permanently trapped in a hyper-immune response that makes them sensitive to innocuous substances. The immune pathway concerned with developing allergy is the Th₂ immune pathway where the IgE antibody binds to its Fc ∊ RI receptor on Mast and Basophil cells. This paper discusses a protocol that could disrupt the binding between the antibody and its receptor for a potential permanent treatment. Ten proteins were computationally designed to display a human IgE motif very close in proximity to the IgE antibody's Fc ∊ RI receptor's binding site in an effort for these proteins to be used as a vaccine against our own IgE antibody. The motif o

SUBMITTER: Sabban SS 

PROVIDER: S-EPMC8403545 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature