Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting.

ABSTRACT:

Background

Studies on the health effects of metal mixtures typically utilize biomarkers measured in a single biological medium, such as blood or urine. However, the ability to evaluate mixture effects are limited by the uncertainty whether a unified medium can fully capture exposure for each metal. Therefore, it is important to compare and assess metal mixtures measured in different media in epidemiology studies.

Objectives

The aim of this study was to examine the mixture predictive performance of urine and blood metal biomarkers and integrated multi-media biomarkers in association with birth outcomes.

Methods

In our analysis of 847 women from the Puerto Rico PROTECT Cohort, we measured 10 essential and non-essential metals in repeated and paired samples of urine and

SUBMITTER: Ashrap P 

PROVIDER: S-EPMC8403638 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature