Effects of the selective dopamine D₃ receptor antagonist PG01037 on morphine-induced hyperactivity and antinociception in mice.

ABSTRACT: Recent preclinical studies have reported that pretreatment with the novel and highly-selective dopamine D₃ receptor (D₃R) antagonists R-VK4-40 or VK4-116 attenuates the abuse-related behavioral effects of oxycodone while enhancing its analgesic properties. However, whether these observed effects are generalizable to the broad class of D₃R antagonists and/or extend to opioids other than oxycodone has not been extensively explored. The present study sought to assess the impact of pretreatment with another selective D₃R antagonist, PG01037, on several behavioral effects of morphine in mice. C57Bl/6 J mice were pretreated with PG01037 (0-10 mg/kg) and tested for 1) hyperlocomotion induced by acute morphine (5.6-56 mg/kg), 2) locomotor sensitization f

SUBMITTER: Botz-Zapp CA 

PROVIDER: S-EPMC8403645 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature