Urinary cadmium and stroke - a case-cohort study in Danish never-smokers.

ABSTRACT:

Background

and Purpose: Cadmium has been associated with risk of cardiovascular events, including stroke. Human cadmium exposure occurs primarily through diet and tobacco smoke. Recent cohort studies have found an association with stroke, but residual confounding from smoking, could not be ruled out. We therefore conducted a case-cohort study to evaluate whether cadmium is associated with stroke in never-smokers.

Methods

The Danish Diet Cancer and Health cohort consists of Danes 50-64 years old, recruited in 1993-1997. From never-smoking cohort members without previous cancer or stroke we sampled a sub-cohort of 1200 persons. We also identified all (n = 534) cases in the cohort with a validated stroke diagnosis between baseline and 2009. We quantified cadmium and creatinine

SUBMITTER: Poulsen AH 

PROVIDER: S-EPMC8403651 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature