Early-life associations between per- and polyfluoroalkyl substances and serum lipids in a longitudinal birth cohort.

ABSTRACT:

Background

Exposures to per- and polyfluoroalkyl substances (PFASs) may affect metabolic outcomes, including lipid concentrations in the blood. However, few studies have evaluated potential associations between PFASs and lipids longitudinally.

Objectives

We estimated associations between PFAS and lipid concentrations at birth and at several points in childhood.

Methods

We measured concentrations of five major PFASs in cord serum and in serum collected at 18 months, five years and nine years in 490 children from a prospective cohort in the Faroe Islands. Total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglyceride (TG) concentrations were measured at birth, 18 months and nine years. We estimated asso

SUBMITTER: Blomberg AJ 

PROVIDER: S-EPMC8403652 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature