The nasal mutualist Dolosigranulum pigrum AMBR11 supports homeostasis via multiple mechanisms.

ABSTRACT: Comparing the nasal microbiome of healthy individuals and chronic rhinosinusitis (CRS) patients revealed Dolosigranulum pigrum as a species clearly associated with nasal health, although isolates obtained from healthy individuals are scarce. In this study, we explored the properties of this understudied lactic acid bacterium by integrating comparative genomics, habitat mining, cultivation, and functional characterization of interaction capacities. Mining 10.000 samples from the Earth Microbiome Project of 17 habitat types revealed that Dolosigranulum is mainly associated with the human nasal cavity. D. pigrum AMBR11 isolated from the nose of a healthy individual exerted antimicrobial activity against Staphylococcus aureus, decreased proinflammatory cytokine prod

SUBMITTER: De Boeck I 

PROVIDER: S-EPMC8403741 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature