Identification of a glycolysis-related lncRNA prognostic signature for clear cell renal cell carcinoma.

ABSTRACT: The present study investigated the independent prognostic value of glycolysis-related long noncoding (lnc)RNAs in clear cell renal cell carcinoma (ccRCC). A coexpression analysis of glycolysis-related mRNAs-long noncoding RNAs (lncRNAs) in ccRCC from The Cancer Genome Atlas (TCGA) was carried out. Clinical samples were randomly divided into training and validation sets. Univariate Cox regression and least absolute shrinkage and selection operator (LASSO) regression analyses were performed to establish a glycolysis risk model with prognostic value for ccRCC, which was validated in the training and validation sets and in the whole cohort by Kaplan-Meier, univariate and multivariate Cox regression, and receiver operating characteristic (ROC) curve analyses. Principal component analysis (PCA)

SUBMITTER: Ma W 

PROVIDER: S-EPMC8403747 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature