Premotor and fronto-striatal mechanisms associated with presence hallucinations in dementia with Lewy bodies.

ABSTRACT:

Introduction

presence hallucinations (PH) are frequent in dementia with Lewy bodies (DLB), but their cortico-subcortical origin is unknown. Recent studies have defined key frontal and temporal areas contributing to the occurrence of PH (PH-network) and tested their relevance in subjects with Parkinson's disease (PD). With the present study, we aimed at disentangling the metabolic and dopaminergic correlates of pH as well as their relation to a recently defined PH brain network in DLB.

Methods

for the present study, we included 34 DLB subjects (10 with PH (PH + ); 24 without PH (PH-)), who underwent ¹⁸F-FDG PET and ¹²³I-FP-CIT SPECT imaging. We performed ¹⁸F-FDG PET group comparisons, as well as interregional correlation analyses using ¹⁸

SUBMITTER: Nicastro N 

PROVIDER: S-EPMC8403753 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature