The many roles of myeloperoxidase: From inflammation and immunity to biomarkers, drug metabolism and drug discovery.

ABSTRACT: This review provides a practical guide to myeloperoxidase (MPO) and presents to the reader the diversity of its presence in biology. The review provides a historical background, from peroxidase activity to the discovery of MPO, to its role in disease and drug development. MPO is discussed in terms of its necessity, as specific individuals lack MPO expression. An underlying theme presented throughout brings up the question of the benefit and burden of MPO activity. Enzyme structure is discussed, including accurate masses and glycosylation sites. The catalytic cycle of MPO and its corresponding pathways are presented, with a discussion of the importance of the redox couples of the different states of MPO. Cell lines expressing MPO are discussed and practically summarized for the reader, and

SUBMITTER: Siraki AG 

PROVIDER: S-EPMC8403760 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature