Naturally acquired HPV antibodies against subsequent homotypic infection: A large-scale prospective cohort study.

ABSTRACT:

Background

Although recent studies have suggested that naturally acquired Human papillomavirus (HPV) antibodies are partly protective against subsequent homotypic infection, the extent of protection remains indecisive. Here, we evaluate the protective effect of neutralizing and IgG antibodies simultaneously.

Methods

In a cohort of 3634 women aged 18-45 years from the control arm of a phase III trial of the HPV-16/18 bivalent vaccine, participants were tested for neutralizing antibodies by pseudovirion-based neutralization assay (PBNA) and IgG antibodies by enzyme-linked immunosorbent assay (ELISA) at baseline. HPV-16/18 incident and persistent infections were identified using cervical specimens periodically collected during the 5·5 years of follow-up. The protective effects

SUBMITTER: Yao X 

PROVIDER: S-EPMC8403914 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature