Electrochemical borylation of carboxylic acids.

ABSTRACT: A simple electrochemically mediated method for the conversion of alkyl carboxylic acids to their borylated congeners is presented. This protocol features an undivided cell setup with inexpensive carbon-based electrodes and exhibits a broad substrate scope and scalability in both flow and batch reactors. The use of this method in challenging contexts is exemplified with a modular formal synthesis of jawsamycin, a natural product harboring five cyclopropane rings.

SUBMITTER: Barton LM 

PROVIDER: S-EPMC8403965 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature