GABA and glutamate in the preterm neonatal brain: In-vivo measurement by magnetic resonance spectroscopy.

ABSTRACT: Cognitive and behavioral disabilities in preterm infants, even without obvious brain injury on conventional neuroimaging, underscores a critical need to identify the subtle underlying microstructural and biochemical derangements. The gamma-aminobutyric acid (GABA) and glutamatergic neurotransmitter systems undergo rapid maturation during the crucial late gestation and early postnatal life, and are at-risk of disruption after preterm birth. Animal and human autopsy studies provide the bulk of current understanding since non-invasive specialized proton magnetic resonance spectroscopy (¹H-MRS) to measure GABA and glutamate are not routinely available for this vulnerable population due to logistical and technical challenges. We review the specialized ¹H-MRS techniques inc

SUBMITTER: Basu SK 

PROVIDER: S-EPMC8404144 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature