Representation of women, older patients, ethnic, and racial minorities in trials of atrial fibrillation.

ABSTRACT:

Background

Representation trends of women, older adults, and ethnic/racial minorities in randomized controlled trials (RCTs) of atrial fibrillation (AF) are uncertain.

Methods

We systematically reviewed 134 AF related RCTs (phase II and III) encompassing 149,162 participants using Medline and ClinicalTrials.gov through April 2019 to determine representation trends of women, older patients (≥75 years), and ethnic/racial minorities. Weighted data on the prevalence of AF from epidemiological studies were used to compare the representation of the studied groups of interest in AF RCTs to their expected burden of the disease.

Results

Only 18.7% of the RCTs reported proportion of older patients, and 12.7% RCTs reported ethnic/racial minorities. The proportions of women in RC

SUBMITTER: Khan MZ 

PROVIDER: S-EPMC8404149 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature