Dissecting human trophoblast cell transcriptional heterogeneity in preeclampsia using single-cell RNA sequencing.

ABSTRACT:

Objective

PE is a pregnancy-specific syndrome that affects 3%-5% of pregnant women. It often presents as new-onset hypertension and proteinuria during the third trimester. PE progresses rapidly and may lead to serious complications, including the death of both mother and fetus. In low-income countries, PE is one of the main causes of maternal and child mortality. While the cause of PE is still debated, clinical and pathological studies suggest that the placenta plays an important role in the pathogenesis of PE.

Materials and methods

In this single-cell RNA-sequencing (RNA-seq) study, the placenta was taken from the designated position after cesarean section. We compared placental cell subsets and their transcriptional heterogeneity between preeclampsia and healthy pregnancie

SUBMITTER: Zhang T 

PROVIDER: S-EPMC8404237 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature