Ontology highlight
ABSTRACT:
SUBMITTER: Benthall KN
PROVIDER: S-EPMC8404511 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Benthall Katelyn N KN Cording Katherine R KR Agopyan-Miu Alexander H C W AHCW Wong Corinna D CD Chen Emily Y EY Bateup Helen S HS
Cell reports 20210801 6
Tuberous sclerosis complex (TSC) is a neurodevelopmental disorder that often presents with psychiatric conditions, including autism spectrum disorder (ASD). ASD is characterized by restricted, repetitive, and inflexible behaviors, which may result from abnormal activity in striatal circuits that mediate motor learning and action selection. To test whether altered striatal activity contributes to aberrant motor behaviors in the context of TSC, we conditionally deleted Tsc1 from direct or indirect ...[more]