Genetic Analysis in Anal and Cervical Cancer: Exploratory Findings About Radioresistance in the ProfiLER Database.

ABSTRACT:

Background/aim

This study aimed to describe genomic alterations on squamous cell cervical and anal carcinomas.

Materials and methods

From 2013 to 2019, 3,269 patients were included in the molecular screening ProfiLER trial. Only patients with non-metastatic cervical or anal cancer, and those initially treated with radiotherapy in a curative intent were selected. Genetic analyses were performed by next generation sequencing (NGS).

Results

Genomic alterations were observed in most patients: 5 patients out of 15 (33.3%) had at least one mutation on NGS and 4 out of 15 (26.7%) had at least one aberration of the number of copies of genes in the comparative genomic hybridation (CGH) analysis. The most common mutated gene was PIK3CA.

Conclusion

All omic approaches mus

SUBMITTER: Rowinski E 

PROVIDER: S-EPMC8404730 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature