Surrounding Greenness and Biological Aging Based on DNA Methylation: A Twin and Family Study in Australia.

ABSTRACT:

Background

High surrounding greenness has many health benefits and might contribute to slower biological aging. However, very few studies have evaluated this from the perspective of epigenetics.

Objectives

We aimed to evaluate the association between surrounding greenness and biological aging based on DNA methylation.

Methods

We derived Horvath's DNA methylation age (DNAmAge), Hannum's DNAmAge, PhenoAge, and GrimAge based on DNA methylation measured in peripheral blood samples from 479 Australian women in 130 families. Measures of DNAmAge acceleration (DNAmAgeAC) were derived from the residuals after regressing each DNAmAge metric on chronological age. Greenness was represented by satellite-derived Normalized Difference Vegetation Index (NDVI) and Enhanced Vegetation

SUBMITTER: Xu R 

PROVIDER: S-EPMC8404778 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature